As 14 years old Niamh Toland from Kerrykeel underwent her life-saving bone marrow transplant in Crumlin Hospital on Tuesday afternoon, her classmates in third year at Loreto College in Milford staged a fundraiser ‘Neon for Niamh’.24 hours after the transplant Niamh’s mother, Brigid reported that the recovery period is going well and the coming days will be important in the first stage of the rehabilitation programme as the medical team monitors the situation, minute by minute.The Tirconaill Tribune reports the procedure on Tuesday morning began at 9.00am when Niamh’s 12 years old brother, Niall was brought to theatre to allow the surgeons to extract one litre of bone marrow along with the stem cells. As Niall remained under anaesthetic, Niamh was already in theatre awaiting the transplant. All went well and with her family and friends urging her to get well, Niamh and indeed Niall have been in everyone’s prayers and thoughts in Kerrykeel throughout the weekend as the deadline approached.Niamh had been admitted to the hospital last Sunday week to undergo five days of chemotherapy and experienced trauma over the weekend. But the planned procedure was completed successfully with Niamh under intense observations in case of any adverse reaction.This has been a very tough time for the Toland and McGinley families and they’ve been highly appreciative of the support of the local community.Niall is big into football and on Tuesday night his biggest concern was that he will have recovered enough to play for the Mulroy Academy at the weekend. So far he has played 25 games for them and has scored 29 goals… but he is real hero having donated his life-saving bone marrow to save his sister’s life on Tuesday.Fundraising events As Niamh recovers from her transplant she faces a lengthy period of recovery and return visits to Crumlin Hospital for another year. She will remain in hospital for up to eight weeks. After being discharged, she will have to return to Crumlin twice weekly for the following ten weeks and this will continue for a year on a reduced basis.A fundraiser acccount towards Niamh’s rehabilitation is to be opened in the Swilly Mulroy Office at the Bridge in Kerrykeel and a committee will be set up trustees on Monday night.A number of fundraisers have been organised locally. Her third year class of students at Loreto Convent, Milford had a sponsored ‘Neon for Niamh’ on Tuesday and on Friday week (October 11th) in Ripple’s Restaurant in Kerrykeel there is a supper night at eight o’clock and your support will be very much appreciated. Please come early and while there is no door charge, donations are welcomed. Your donation will see you included in a spot prize draw. The music is by Shane McLaughlin and the House Band and it will be a great way of supporting the fundraising.John Og Friel is organising a 25 card drive in the Mulroy Woods Hotel on Friday night, October 25th at 8.00pm and you are asked to contact John Friel for details on 086 3838795.On Saturday October 26th there is a vintage tractor run in aid of Niamh’s fund. This event is in the Church Grounds in Kerrykeel with registration at 11.00am.The man to contact for details is John Ward on 087 7771655. Please support all these events and keep contributing to the gofundme. Niamh Toland Rehabilitation Fund page to help reach the target figure of €20,000.Kerrykeel girl undergoes successful life-saving transplant was last modified: October 3rd, 2019 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)Tags:donegalKERRYKEELNimah Tolandtransplant
Eden Hazard went off injured during the first half at the King Power Stadium, where Jamie Vardy put Leicester ahead.Blues playmaker Hazard was replaced by Pedro on 28 minutes with what looked like a hip problem following a challenge from Vardy, who scored five minutes later.Riyad Mahrez, who had two early efforts gathered by keeper Thibaut Courtois, delivered a superb cross from the right and striker Vardy volleyed home his 15th goal of the season.The Foxes were forced into a change of their own when Danny Drinkwater picked up a hamstring injury after a quarter of an hour.But they remained on the front foot and Vardy’s goal put them within sight of a win that would take them back to the top of the Premier League.Chelsea: Courtois; Ivanovic, Zouma, Terry, Azpilicueta; Ramires, Matic; Willian, Oscar, Hazard (Pedro 31); Costa.Subs: Begovic, Cahill, Mikel, Fabregas, Kenedy, Remy.Follow West London Sport on TwitterFind us on Facebook
SAN JOSE – Joe Staley wanted it documented: He didn’t just hop on the San Jose Sharks bandwagon that sledded toward the Western Conference final.“I’ve been a long-time Sharks fan,” Staley, the 49ers’ left tackle, said before Wednesday night’s Game 7 win against Colorado.Staley, a 13th-year veteran, is leading a slew of 49ers now moonlighting as unabashed Sharks groupies. At least 16 players attended Game 7.Related Articles Jimmy Garoppolo in a class with iconic one-name QBs, …
1Stupack et al., “Potentiation of neuroblastoma metastasis by loss of caspase-8,” Nature 439, 95-99 (5 January 2006) | doi:10.1038/nature04323.2Breitz et al., “Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons,” Proceedings of the National Academy of Sciences USA, published online before print January 3, 2006, 10.1073/pnas.0507225103.3Bik et al., “Molecular analysis of the bacterial microbiota in the human stomach,” Proceedings of the National Academy of Sciences USA, published online before print January 4, 2006, 10.1073/pnas.0506655103.4Barsky and Venclovas, “DNA Sliding Clamps: Just the Right Twist to Load onto DNA,” Current Biology, Volume 15, Issue 24, 24 December 2005, pages R989-R992.5Gore et al., “Mechanochemical analysis of DNA gyrase using rotor bead tracking,” Nature 439, 100-104 (5 January 2006) | doi:10.1038/nature04319.6Dumont et al., “RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP,” Nature 439, 105-108 (5 January 2006) | doi:10.1038/nature04331.Most of these articles mentioned little or nothing about evolution. Here is legitimate science in action: seeking understanding, observing phenomena in real time, learning things so as to benefit human health. Was Darwinism valuable in the slightest? These articles are mere glimpses into the new world of molecular machines for which evolutionary theory was completely unprepared. Most of these machines are parts of complexes with other machines, and they all must meet precise specs or they won’t work – and not working often means serious impairment or death. How could such elaborate factories emerge by mindless, undirected processes of evolution? Darwinists are either scrambling to patch up their theory with new just-so stories, or else going schizophrenic by not even attempting to explain these machines on one side of their head while stating “evolution is a fact, like gravity” on the other. Any thinking person examining evidence like this will quickly tire of the “maybe this, maybe that” habit of the Darwin Party: “perhaps in some warm little pond, the first life needed a way to pack DNA, so it invented gyrase.” Yeah, right. Preach it, brother. Charlie was plagued by stomach aches most of his life. Had he knowledge of such small wonders, his groans might have been heard round the world. Those not infected with Gastroenteritis darwini can avoid infection by clicking back through five years of Chain Links on Cell Biology and Amazing Stories. Doing so has the added benefit of inducing a state of euphoria, also known as intelligent worship.(Visited 16 times, 1 visits today)FacebookTwitterPinterestSave分享0 When we think of health, we typically visualize the big things: firm muscles, energy, lack of a protruding stomach and the like. Cell biology, though, is showing us how our health depends on the proper functioning of countless myriads of molecular machines. Here are some recent samples from the science journals:Heroic Underdogs in the Brain: Neurons always got the glory in neurology studies, but now it appears that structural cells called astrocytes deserve more respect. A summary of work at U. of Rochester posted on EurekAlert says that these “housekeeping” cells actually perform critical functions in regulating blood flow. They “play a direct role in controlling blood flow in the brain, a crucial process that allows parts of the brain to burst into activity when needed.” When they malfunction, they might contribute directly to degenerative maladies like Alzheimer’s disease. See also LiveScience.The Vital Destroyer: When cancer spreads, hope shrinks. Friends and family of cancer victims know the agony of metastasis. At least in some kinds of cancers, metastasis may be traced to failure of a protein named caspase-8 that acts like a curfew cop. Normally, reported EurekAlert about work by St. Jude’s Research Hospital, caspase-8 patrols the surfaces of tissues looking for vagrant cells that have dislodged from their normal locations and are wandering into unsafe territory. When it finds them, it turns on their built-in self-destruct program, called apoptosis. When the cops are out sick, the vagrants get out and cause trouble. The paper was published in Nature.1Your Third Eye: A rare type of eye cell can see. Rods and cones, we know, do most of the real-time visualization, but scientists at Brown University found “intrinsically photosensitive retinal ganglion cells,” or ipRGCs, that respond to light and are hardwired to the brain. They are pretty sure these slower-acting light sensors are responsible for setting our biological clock and controlling the iris muscles, regulating how much light enters the eye. “These cells operate like a light meter on a camera,” said researcher David Berson. “They tell the brain to constrict the pupil based on the amount of light registered over time.” There are about 2,000 of these cells in the eye, compared to millions of rods and cones.Don’t Bang the Eardrums: Our ears can tolerate many orders of magnitude in volume, but there are limits. Researchers at Ohio State found that “years of repeated exposure to loud noise increases the risk of developing a non-cancerous tumor that could cause hearing loss.” Please pass this warning along to your local fitness center.Watergate Scandal: Point mutations to our water gates, the water-regulating channels in cell membranes, can let the wrong substances in, reported Breitz et al. in PNAS.2 These elaborate channels made of protein, called aquaporins, depend on a precise amino-acid structure to authenticate water but keep other similar-size molecules out; they can even keep out tiny protons. The team inserted mistakes here and there and found that contraband like urea or glycerol could sneak in. One amazing factoid they mentioned is that a single red blood cell has as many as 200,000 aquaporins. For more on membrane channels, see 05/29/2002 and 12/20/2001. A reader found detailed powerpoint presentations and animations at the University of Illinois at Urbana-Champaign website, and more at the University of Maine.Gutfull Wonders The stomach is a lively place. Lots of organisms live there; hope you don’t mind. A team from Stanford and NYU decided to start surveying these one-celled companions, because “The microbiota of the human stomach … remain largely unknown.” Their preliminary results, published in PNAS,3 began, “A diverse community of 128 phylotypes was identified, featuring diversity at this site greater than previously described.” Ten percent of them were previously unknown, and they come from at least five separate phyla. Surprisingly, the population in the stomach differs from that in the mouth and esophagus, and different people have different assortments. There are some known bad bugs like Helicobacter pylori that form ulcers, but most of them must be OK or even helpful, since we usually feel good after a big meal: “The gastric microbiota may play important, as-yet-undiscovered roles in human health and disease,” they said.Clamp Champs: You have sliding clamps in your cells. Really. Current Biology4 talked about these wonderful machines that twist DNA during the copy process:DNA sliding clamps were first characterized as DNA polymerase processivity factors: without their presence, cell division would be inconceivably slow; replication of long stretches of DNA would be hopelessly inefficient because DNA polymerases tend to fall off the DNA after elongating a strand by just a handful of bases. By tethering the polymerase to the DNA, such processivity factors enable the polymerase to add thousands of bases in a few seconds without detaching from the DNA. (Emphasis added in all quotes.)They work kind of like magic Chinese linking rings. Somehow they melt around the DNA strand without harming it. This allows all the other machinery to get a grip during that heavy-duty copying cycle. Good thing we don’t have to wait so long for the copy operation or we might never grow up.DNA Gyrations During Packaging: Nature printed articles on two other DNA motors that deserve special notice: one is an acrobatic “gyrase” that generates negative supercoils in DNA (that’s important for packing and safety during cell division).5 In their words, “Negative DNA supercoiling is essential in vivo to compact the genome, to relieve torsional strain during replication, and to promote local melting for vital processes such as transcript initiation by RNA polymerase.” The little motor runs on the cell’s special fuel pellets, ATP. The scientists put beads on it and watched it spin around. They found it was quite sensitive to tension.More DNA Acrobatics: Another team publishing in Nature6 studied motors called DNA helicases, which are “involved in nearly all aspects of DNA and RNA metabolism.” Utilizing special techniques, they watched this incredibly tiny molecular motor and discovered that it “might move like an inchworm” (that’s scientific lingo). It also runs on ATP in a precise range of stresses. Without the helicase machinery, DNA unfolding would be very, very slow. This particular helicase, named NS3, is just one of many “helicases involved in many essential cellular functions.”
Janine Erasmus“Globe research for sustainable communities” will be the theme when the annual Global Learning and Observations to Benefit the Environment (Globe) conference takes place in Cape Town in June 2008.Globe is an organisation that offers students the chance to gain hands-on experience in genuine science, conducting their own research in their own communities towards a better understanding of how the earth works. Since the organisation’s inception in 1995, Globe conferences have been held outside the US only twice, and this year’s event will mark the third such occasion, as well as an African first.The annual Globe conference offers participants the opportunity to familiarise themselves with the latest environmental research, as well as new developments in the Globe programme. Relevant issues come under discussion during the science, education and implementation panels as well as in workshop sessions, and the day activities in the field.A Globe Learning Expedition will also take place – another first for Africa. Learning expeditions are held every few years to expose students from around the world to the Globe scientific community at large, and to allow them to present their projects to an interested international audience. Participants also get an opportunity to network and establish partnerships with their peers through Globe, and teachers are able to share their ideas and challenges.The last learning expedition took place in Šibenik, Croatia, in 2003. Previously, learning expeditions were held in Fayetteville, Arkansas, US, in 2000 and in Helsinki, Finland, in 1998.Scientific research helping to create sustainable communitiesThe underlying concept of the theme of the 2008 learning expedition, “Globe research for sustainable communities”, is that of understanding the link between the environment and the needs of the community, with the aim of finding the balance. Students use their own communities as research subjects, using Globe data to help them answer questions about how the environment around them works. Research projects teach students to create hypotheses, analyse their data, draw conclusions and report their results, thereby adding to the global pool of data.Specific topics that will come under discussion at this year’s learning experience include the environment and human health, specifically with relation to diseases like malaria and tuberculosis, as well as issues relating to water quality and climate change. These are all issues that affect Africa significantly, and students are encouraged to engage in relevant research that will benefit their communities and, ultimately, the environment.In addition, projects in any of the four basic spheres of Globe research may be presented – these are watershed dynamics (where students conduct research into understanding water dynamics in their region); local to extreme environments (a study of the deep ocean led by Pennsylvania State University); seasons and biomes (collecting data related to regional climate change, prevention and management of diseases, and understanding of the water and carbon cycles); and the carbon cycle specifically. The application of indigenous knowledge systems to any of these fields is encouraged.Bringing the world’s scientific community togetherGlobe came into being in 1994 and commenced its operation on Earth Day 1995. The network now spans 110 countries, with over 40 000 Globe-trained teachers from 20 000 schools around the world. The organisation’s close work with the US-based National Aeronautic and Space Administration and National Science Foundation ensures that the entire Globe community has access to the world’s top scientists and the most up-to-date research in earth system science.The Globe network gathers teachers, students and scientists together for a better understanding of the environment on local, regional, national and international level. The goal is to work together to sustain and improve the environment, promote scientific discovery in this field, and boost awareness of the importance of caring for the earth, as well as inspiring the next generation of scientists.South Africa joined the programme in 1997. The then US vice president Al Gore and South African deputy president Thabo Mbeki signed an agreement in Cape Town that made South Africa the 47th country to join the programme.Today there are over 90 participating schools situated all around the country. The Globe programme is co-ordinated by the South African Environmental Observation Network in collaboration with the Science and Youth Unit in the Ministry of Science and Technology. South Africa hosts regional meetings and teacher training workshops on a regular basis.Globe earned a Goldman Sachs Foundation Prize in 2004. Established in 2003, these awards recognise excellence in international education amongst US schools.Useful linksGlobeGlobe in AfricaGoldman Sachs FoundationDepartment of Science and TechnologySouth African Environmental Observation NetworkNational Research Foundation
2 November 2012A team of professionals responsible for maintenance of all equipment will now be stationed at four hospitals in South Africa’s Gauteng province, Infrastructure Development MEC Qedani Mahlangu announced in Johannesburg on Wednesday.Mahlangu said the teams – to be stationed at the Charlotte Maxeke and Chris Hani Baragwanath Academic Hospitals in Johannesburg, and the Steve Biko Academic and Dr George Mukhari Hospitals in Pretoria – will include mechanical and electrical engineers, as well as quantity and supporting artisans.“They will be responsible for maintaining all equipment, conducting preventative maintenance, drafting specifications and project scoping,” she said.Progress in infrastructure and maintenanceMahlangu did an inspection on three facilities, including the massive Chris Hani Baragwanath, which is currently undergoing infrastructure upgrades.The inspection at Chris Hani Baragwanath and Charlotte Maxeke was followed by a visit to Zola/Jabulani Hospital in Soweto, southwest of Johannesburg, which is due to be completed early next year.The aim of the inspection was to check the progress made regarding infrastructure and maintenance in the hospitals.During her visit to Chris Hani Baragwanath, Mahlangu checked the progress in the building of a new ICU ward, chillers, boilers, lifts and generators.“I’m comfortable. It’s all systems go, especially at the ICU. Doctors resting rooms have been improved and patients would be moved to a new ICU ward on 15 November 2012,” she said.“Out of four boilers, two are working and sufficient to deliver services, the other two, which are currently not working, will be fixed by the end of next week.”Natural gas is also scheduled to be installed and used in the hospitals next year.Monitoring of deadlinesRegarding the problem of lifts not working at Charlotte Maxeke Hospital, Mahlangu explained that the problem was due to the shortage of manufacturers but promised to meet with them to find a solution.“I’m pleased we are doing the work and confident that the timelines are there. I will monitor if the deadlines [for repairs and new buildings under way] have been met,” she said.She acknowledged that they have also experienced several challenges in the construction of Jabulani Hospital, with some delays related to the payment of the contractors, but said they are committed to resolving these matters.Earlier this year, the department reached an agreement with the provincial Health Department for minor maintenance functions to be transferred to the hospitals’ chief executive officers in order to address turnaround times.Together with the allocated budget, the CEO’s will be responsible for purchasing material and managing maintenance for minor work under R1-million.Source: SANews.gov.za
Share Facebook Twitter Google + LinkedIn Pinterest Several pipeline projects are crisscrossing the state. While some landowners are just seeing equipment and workers show up on their property, others are seeing pipelines be buried and the land being reclaimed. Some Ohio landowners question whether pipelines on their property and reclamation of the land are being carried out properly. Safety issues related to construction of pipelinesIn certain circumstances, landowners with completed pipelines on their property can contact the Public Utilities Commission of Ohio (PUCO) with their concerns. PUCO has the authority to oversee safety issues on completed pipelines in Ohio. If a landowner is concerned that an existing pipeline on their property has a legitimate safety issue, that landowner should contact PUCO to report suspected safety issues. PUCO inspectors may issue a noncompliance letter to pipeline companies, if a violation is discovered.If the landowner specifically suspects that the pipeline company is not following recommended standards and construction specifications, local Soil and Water Conservation Districts or the Ohio Department of Agriculture (ODA) may be able to assist. By law ODA must cooperate with other agencies to protect the agricultural status of rural lands adjacent to projects such as pipelines. ODA publishes model pipeline standard and construction specifications intended to limit the impact of construction of a pipeline on agricultural productivity. Contract disagreement issues (non-safety issues)If a landowner has an issue that is not related to safety, that issue may be addressed in the easement agreement between the landowner and the pipeline company. A pipeline easement is a contract. Both parties agree to uphold their obligations under the contract. Essentially, the landowner agrees to provide subsurface land and access rights to a pipeline company in return for monetary compensation.Of course, an easement is much more complicated than that. As part of this contractual relationship, a landowner has the right to request that the pipeline company uphold their duties under the contract. If a landowner doesn’t believe that a pipeline company is following the terms of an easement, the landowner has the right to enforce the agreement. While the landowner may seek an attorney to do this, it may be best to work with the pipeline company first.Landowners should consider keeping detailed notes of issues as they arise. For example, a landowner may wish to take written notes on and photographs of the property after noticing a construction issue. This may be helpful in presenting the issue to the pipeline company. It may be cheaper and faster to raise the issue with the pipeline company first, before speaking with an attorney. However, if a landowner’s complaints aren’t resolved in a timely manner after speaking with the company, the landowner will want to speak with an attorney to enforce the contract. What to remember when speaking with a pipeline company representativeAs a practical note, it is important for a landowner to realize that the workers on a pipeline might not be from the pipeline company itself. For example, if a landowner has an issue with the way that the easement is re-soiled and re-planted, it could be a third party that did the work. Landowner’s should re-read their easement to ensure that sub-contracting is allowed. When a landowner calls a company, he or she should realize that the company may not have done the work, but rather a subcontractor completed the work. Therefore, the landowner should fully describe the issue to the pipeline company so that the company understands the issue. Any evidence, such as photographs or written notes may be very helpful in resolving an issue with the pipeline company.It is always best to identify potential issues early. Landowners may want to check the progress of pipeline construction on their property as it occurs. If there is an issue, landowners should promptly contact the company. Landowners should check their easement agreement to see if the easement outlines a process to dispute terms of the agreement.If the contract does not outline a process to dispute terms of the agreement, it would be best for landowners to speak with the construction foreman first, then moving up the management chain if the company doesn’t react favorably. If the company and the landowner can’t come to a resolution, the landowner may need an attorney at some point.Reclamation of the LandAfter a pipeline is buried, the soil and the surface of the land is ideally placed back in its original condition. This process is sometimes referred to as reclamation. The pipeline easement agreement between a landowner and a pipeline company usually discusses how this process will be completed. Landowners and pipeline companies often agree beforehand how the land will be reclaimed after the pipeline is constructed. Pipelines may disturb trees, soil, and waterways during the construction process. These disturbances may impact crop yields and grazing habits in future years. For this reason, landowners may wish to carefully monitor the reclamation process and enforce the terms of the easement. Living with a pipeline easementWhen landowners have concerns or questions regarding a pipeline on their property, the best place to start is the pipeline easement. Landowners may have recently signed an easement, or landowners may be subject to a pre-existing easement signed by a previous owner of the property. Current landowners are subject to pre-existing easements, because easements “run with the land.” Old easements don’t typically expire, unless the original easement language provides for extinguishment of the easement under certain circumstances (for example, abandonment the easement).Pipelines are a common tool for the transportation of natural resources. Many Ohio landowners have pipelines crisscrossing their property. Landowners should raise any pipeline safety or construction issues with the appropriate state agency, and any contractual issues should be brought to the pipeline company. As always, a landowner should pay careful attention to the language of the pipeline easement in determining how to approach a potential problem.More information on pipeline easements is here.
Low cabin pressure mid-air forced a Delhi-bound SpiceJet aircraft from Mumbai, carrying over 100 passengers, to land at the city airport this morning under emergency conditions. All the passengers on-board were safe, an airline spokesperson said.“SpiceJet Boeing 737 aircraft (VT-SZB) was operating flight SG 160 Mumbai-Delhi. Enroute, the aircraft had a (cabin) pressure problem,” the SpiceJet spokesperson said. Following the standard operating procedure, the crew diverted the aircraft to Ahmedabad, where it landed safely, he added. There were over 100 passengers on-board the plane, the spokesperson said.